An artificial intelligence-generated model predicts 90-day survival in alcohol-associated hepatitis: A global cohort study.

Journal: Hepatology (Baltimore, Md.)
Published Date:

Abstract

BACKGROUND AND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence in a global cohort, we sought to derive and validate an enhanced prognostic model.

Authors

  • Winston Dunn
    Department of Gastroenterology, University of Kansas Medical Center, Kansas, USA.
  • Yanming Li
    Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.
  • Ashwani K Singal
    Department of Gastroenterology and Hepatology, University of Louisville, Louisville, Kentucky, USA.
  • Douglas A Simonetto
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
  • Luis A Diaz
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Francisco Idalsoaga
    Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Gustavo Ayares
    Department of Medicine, Servicio Medicina Interna, Hospital El Pino, Santiago, Chile.
  • Jorge Arnold
    Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • María Ayala-Valverde
    Department of Medicine, Servicio Medicina Interna, Hospital El Pino, Santiago, Chile.
  • Diego Perez
    Department of Medicine, Servicio Medicina Interna, Hospital El Pino, Santiago, Chile.
  • Jaime Gomez
    Department of Medicine, Servicio Medicina Interna, Hospital El Pino, Santiago, Chile.
  • Rodrigo Escarate
    Department of Medicine, Servicio Medicina Interna, Hospital El Pino, Santiago, Chile.
  • Eduardo Fuentes-López
    Department of Health Sciences, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Carolina Ramirez-Cadiz
    Department of Anesthesiology and Perioperative Medicine, Schulich School of Medicine, Western University and London Health Sciences Centre, London, Ontario, Canada.
  • Dalia Morales-Arraez
    Department of Medicine, Center for Liver Diseases, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pennsylvania, USA.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Steve Qian
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Florida, Gainesville, Florida, USA.
  • Joseph C Ahn
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Seth Buryska
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
  • Heer Mehta
    Department of Gastroenterology, University of Kansas Medical Center, Kansas, USA.
  • Nicholas Dunn
    Department of Gastroenterology, University of Kansas Medical Center, Kansas, USA.
  • Muhammad Waleed
    Department of Gastroenterology and Hepatology, University of Louisville, Louisville, Kentucky, USA.
  • Horia Stefanescu
    Regional Institute of Gastroenterology and Hepatology "O Fodor", Gastroenterology Department, Cluj-Napoca, Romania.
  • Andreea Bumbu
    Department of Medicine, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.
  • Adelina Horhat
    University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania.
  • Bashar Attar
    Division of Gastroenterology and Hepatology, Department of Medicine, Cook County Health, and Hospital Systems, Chicago, Illinois, USA.
  • Rohit Agrawal
    Division of Gastroenterology and Hepatology, Department of Medicine, University of West Virginia, West Virginia, USA.
  • Joaquín Cabezas
    Department of Gastroenterology and Hepatology, University Hospital Marqués de Valdecilla, Santander, Spain.
  • Victor Echavaría
    Department of Gastroenterology and Hepatology, University Hospital Marqués de Valdecilla, Santander, Spain.
  • Berta Cuyàs
    Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Hospital de Sant Pau-IIB Sant Pau, Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.
  • Maria Poca
    Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Hospital de Sant Pau-IIB Sant Pau, Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.
  • German Soriano
    Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Hospital de Sant Pau-IIB Sant Pau, Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.
  • Shiv K Sarin
    Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
  • Rakhi Maiwall
    Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
  • Prasun K Jalal
    Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, USA.
  • Fátima Higuera-de-la-Tijera
    Department of Medicine, Servicio de Gastroenterología y Hepatología, Hospital General de México "Dr. Eduardo Liceaga"; Facultad de Medicina, Universidad Nacional Autónoma de México, México.
  • Anand V Kulkarni
    Department of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
  • P Nagaraja Rao
    Department of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
  • Patricia Guerra-Salazar
    Instituto de Gastroenterología Boliviano-Japonés, Cochabamba, Bolivia.
  • Ľubomír Skladaný
    II. Internal Clinic SMU, Dpt. of Hepatology, Gastroenterology and Liver Transplantation, F. D. Roosevelt Teaching Hospital, Banska Bystrica, Slovak Republic, e-mail: silvia.kasova@gmail.com.
  • Natália Kubánek
    Department of Internal Medicine II, Division of Hepatology, Gastroenterology and Liver Transplantation, Slovak Medical University, F. D. Roosevelt University Hospital, Banska Bystrica, Slovak Republic.
  • Veronica Prado
    Department of Medicine, Centre Hospitalier de Luxembourg, Luxembourg.
  • Ana Clemente-Sanchez
    Department of Medicine, Center for Liver Diseases, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pennsylvania, USA.
  • Diego Rincon
    Department of Digestive Diseases, Liver Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Tehseen Haider
    Division of Gastroenterology and Hepatology, Department of Medicine, Montefiore Medical Center, Bronx, New York, USA.
  • Kristina R Chacko
    Division of Gastroenterology and Hepatology, Department of Medicine, Montefiore Medical Center, Bronx, New York, USA.
  • Gustavo A Romero
    Department of Medicine, Sección Hepatología, Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina.
  • Florencia D Pollarsky
    Department of Medicine, Sección Hepatología, Hospital de Gastroenterología Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina.
  • Juan C Restrepo
    Unidad de Hepatología del Hospital Pablo Tobon Uribe, Grupo de Gastrohepatología de la Universidad de Antioquia, Medellín, Colombia.
  • Luis G Toro
    Department of Medicine, Hepatology and Liver Transplant Unit, Hospitales de San Vicente Fundación de Medellín y Rionegro, Colombia.
  • Pamela Yaquich
    Departamento de Gastroenterología, Hospital San Juan de Dios, Santiago, Chile.
  • Manuel Mendizabal
    Department of Medicine, Hepatology and Liver Transplant Unit, Hospital Universitario Austral, Buenos Aires, Argentina.
  • Maria L Garrido
    Hospital Central San Luis, San Luis, Argentina.
  • Sebastián Marciano
    Department of Medicine, Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
  • Melisa Dirchwolf
    Department of Medicine, Unidad de Hígado, Hospital Privado de Rosario, Rosario, Argentina.
  • Victor Vargas
    Department of Medicine, Liver Unit, Hospital Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.
  • César Jiménez
    Department of Medicine, Liver Unit, Hospital Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, CIBERehd, Barcelona, Spain.
  • David Hudson
    Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University and London Health Sciences Centre, London, Ontario, Canada.
  • Guadalupe Garcia-Tsao
    Section of Digestive Diseases, Department of Medicine, Yale School of Medicine, New Haven, USA.
  • Guillermo Ortiz
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine/VA-CT Healthcare System, New Haven, CT, USA.
  • Juan G Abraldes
    Division of Gastroenterology, Department of Medicine, Liver Unit, University of Alberta, Edmonton, Canada.
  • Patrick S Kamath
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Marco Arrese
    Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Vijay H Shah
    Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MA, USA.
  • Ramon Bataller
    Department of Medicine, Liver Unit, Hospital Clinic, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Juan Pablo Arab
    Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.