Evolving Therapeutic Landscape of Intracerebral Hemorrhage: Emerging Cutting-Edge Advancements in Surgical Robots, Regenerative Medicine, and Neurorehabilitation Techniques.

Journal: Translational stroke research
PMID: 38558011

Abstract

Intracerebral hemorrhage (ICH) is the most serious form of stroke and has limited available therapeutic options. As knowledge on ICH rapidly develops, cutting-edge techniques in the fields of surgical robots, regenerative medicine, and neurorehabilitation may revolutionize ICH treatment. However, these new advances still must be translated into clinical practice. In this review, we examined several emerging therapeutic strategies and their major challenges in managing ICH, with a particular focus on innovative therapies involving robot-assisted minimally invasive surgery, stem cell transplantation, in situ neuronal reprogramming, and brain-computer interfaces. Despite the limited expansion of the drug armamentarium for ICH over the past few decades, the judicious selection of more efficacious therapeutic modalities and the exploration of multimodal combination therapies represent opportunities to improve patient prognoses after ICH.

Authors

  • Danyang Chen
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Zhixian Zhao
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Shenglun Zhang
    School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Shiling Chen
    Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. chensl_92@vip.163.com.
  • Xuan Wu
    Department of Dermatology, First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • Jian Shi
  • Na Liu
  • Chao Pan
    Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
  • Yingxin Tang
    Independent Researcher, Changsha 410000, China.
  • Cai Meng
    School of Astronautics, Beihang University, Beijing, China.
  • Xingwei Zhao
    School of Mechanical Science & Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
  • Bo Tao
    Department of Radiology, the Center for Medical Imaging, West China Hospital of Sichuan University, China.
  • Wenjie Liu
    School of Chemical Science and Engineering, Tongji University, 1239 Siping Rd, Shanghai, 200092, PR China. tmyao@tongji.edu.cn ao.huang@tcichemicals.com.
  • Diansheng Chen
  • Han Ding
    State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
  • Ping Zhang
    Department of Computer Science and Engineering, The Ohio State University, USA.
  • Zhouping Tang
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ddjtzp@163.com.

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