Deep Learning-Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome.

Journal: JAMA cardiology
PMID: 38446445

Abstract

IMPORTANCE: Congenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline-normal QT interval despite LQTS often being detected by QT prolongation on resting electrocardiography (ECG).

Authors

  • River Jiang
    Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Christopher C Cheung
    Division of Cardiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
  • Marta Garcia-Montero
    Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
  • Brianna Davies
    Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Jason Cao
    Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Damian Redfearn
    Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
  • Zachary M Laksman
    Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Steffany Grondin
    Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
  • Joseph Atallah
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
  • Carolina A Escudero
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
  • Julia Cadrin-Tourigny
    Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
  • Shubhayan Sanatani
    Children's Heart Centre, BC Children's Hospital, Vancouver, British Columbia, Canada.
  • Christian Steinberg
    Institut Universitaire de Cardiologie et Pneumologie de Quebec, Laval University, Quebec City, Quebec, Canada.
  • Jacqueline Joza
    Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
  • Robert Avram
    Division of Cardiology, Department of Medicine, Montreal Heart Institute, University of Montreal, Montreal, QC H1T 1C8, Canada. Electronic address: robert.avram.md@gmail.com.
  • Rafik Tadros
    Montreal Heart Institute, Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
  • Andrew D Krahn
    Center for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: akrahn@mail.ubc.ca.

Keywords

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