Proximal femur fracture detection on plain radiography via feature pyramid networks.

Journal: Scientific reports
PMID:

Abstract

Hip fractures exceed 250,000 cases annually in the United States, with the worldwide incidence projected to increase by 240-310% by 2050. Hip fractures are predominantly diagnosed by radiologist review of radiographs. In this study, we developed a deep learning model by extending the VarifocalNet Feature Pyramid Network (FPN) for detection and localization of proximal femur fractures from plain radiography with clinically relevant metrics. We used a dataset of 823 hip radiographs of 150 subjects with proximal femur fractures and 362 controls to develop and evaluate the deep learning model. Our model attained 0.94 specificity and 0.95 sensitivity in fracture detection over the diverse imaging dataset. We compared the performance of our model against five benchmark FPN models, demonstrating 6-14% sensitivity and 1-9% accuracy improvement. In addition, we demonstrated that our model outperforms a state-of-the-art transformer model based on DINO network by 17% sensitivity and 5% accuracy, while taking half the time on average to process a radiograph. The developed model can aid radiologists and support on-premise integration with hospital cloud services to enable automatic, opportunistic screening for hip fractures.

Authors

  • İlkay Yıldız Potter
    BioSensics, LLC, 57 Chapel Street, Newton, MA, 02458, USA. ilkay.yildiz@biosensics.com.
  • Diana Yeritsyan
    Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, 330 Brookline Avenue, Stoneman 10, Boston, MA, 02215, USA.
  • Sarah Mahar
    Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, 330 Brookline Avenue, Stoneman 10, Boston, MA, 02215, USA.
  • Nadim Kheir
    Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, 330 Brookline Avenue, Stoneman 10, Boston, MA, 02215, USA.
  • Aidin Vaziri
    BioSensics, LLC, 57 Chapel Street, Newton, MA, 02458, USA.
  • Melissa Putman
    Division of Endocrinology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
  • Edward K Rodriguez
    Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, 330 Brookline Avenue, Stoneman 10, Boston, MA, 02215, USA.
  • Jim Wu
    Department of Radiology, Massachusetts General Brigham (MGB) and Harvard Medical School, 75 Francis Street, Boston, MA, 02215, USA.
  • Ara Nazarian
    Carl J. Shapiro Department of Orthopaedic Surgery Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA.
  • Ashkan Vaziri
    BioSensics, LLC, Newton, MA, USA.