Investigation of the usefulness of a bile duct biopsy and bile cytology using a hyperspectral camera and machine learning.

Journal: Pathology international
PMID:

Abstract

To improve the efficiency of pathological diagnoses, the development of automatic pathological diagnostic systems using artificial intelligence (AI) is progressing; however, problems include the low interpretability of AI technology and the need for large amounts of data. We herein report the usefulness of a general-purpose method that combines a hyperspectral camera with machine learning. As a result of analyzing bile duct biopsy and bile cytology specimens, which are especially difficult to determine as benign or malignant, using multiple machine learning models, both were able to identify benign or malignant cells with an accuracy rate of more than 80% (93.3% for bile duct biopsy specimens and 83.2% for bile cytology specimens). This method has the potential to contribute to the diagnosis and treatment of bile duct cancer and is expected to be widely applied and utilized in general pathological diagnoses.

Authors

  • Tomoko Norose
    Department of Pathology, Shizuoka Cancer Center, Shizuoka, 411-8777, Japan.
  • Nobuyuki Ohike
    Department of Pathology, Shizuoka Cancer Center, Shizuoka, 411-8777, Japan.
  • Daiki Nakaya
    Milk. Inc, Tokyo, Japan.
  • Kentaro Kamiya
    Milk. Inc, Tokyo, Japan.
  • Yoshiya Sugiura
    Division of Molecular Pathology, Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Misato Takatsuki
    Division of Molecular Pathology, Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Hirotaka Koizumi
    Division of Molecular Pathology, Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Chie Okawa
    Division of Pathology, St. Marianna University Hospital, Kawasaki, Japan.
  • Aya Ohya
    Division of Pathology, St. Marianna University Hospital, Kawasaki, Japan.
  • Miyu Sasaki
    Division of Pathology, St. Marianna University Hospital, Kawasaki, Japan.
  • Ruka Aoki
    Division of Pathology, St. Marianna University Hospital, Kawasaki, Japan.
  • Kazunari Nakahara
    Department of Gastroenterology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Shinjiro Kobayashi
    Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Keisuke Tateishi
    Department of Gastroenterology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Junki Koike
    Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.