BACKGROUND: To develop and validate a deep learning pipeline using prostate biopsy H&E slides to predict extraprostatic extension (EPE) in prostate cancer (PCa) patients.
Diagnostic needle biopsies that miss clinically significant prostate cancer (PCa) often sample benign tissue near hidden cancers. Such benign samples might still display subtle morphological signs of cancer elsewhere in the prostate. This study exami...
Longitudinal serological proteomic dynamics during antiviral therapy (AVT) in chronic hepatitis B (CHB) patients with liver fibrosis remain poorly characterized. Here, using four-dimensional data-independent acquisition mass spectrometry (4D-DIA-MS),...
The Nancy histological index (NHI) is a measure of disease activity within colorectal biopsies and a predictor of clinical outcome in ulcerative colitis (UC). We measured interobserver agreement (IOA) during NHI scoring of 20 colorectal biopsies in U...
OBJECTIVES: Renal biopsy is the gold standard for the diagnosis of glomerular diseases including membranous nephropathy (MN), however, it faces challenges in accuracy, objectivity, and reproducibility of tissue evaluation. This study aims to develop ...
INTRODUCTION: Histopathological evaluation of prostate biopsies using the Gleason scoring system is critical for prostate cancer diagnosis and treatment selection. However, grading variability among pathologists can lead to inconsistent assessments, ...
BACKGROUND: Multiparametric magnetic resonance imaging (mpMRI) has significantly advanced prostate cancer (PCa) detection, yet decisions on invasive biopsy with moderate prostate imaging reporting and data system (PI-RADS) scores remain ambiguous.
Approximately 40% of patients with rheumatoid arthritis do not respond to individual biologic therapies, while biomarkers predictive of treatment response are lacking. Here we analyse RNA-sequencing (RNA-Seq) of pre-treatment synovial tissue from the...
Helicobacter pylori (HP) have chronically infected more than half of the world's population and is a cause of chronic gastritis, peptic ulcers and gastric carcinoma. The manual detection of HP in a glass slide with a microscope is extremely time-cons...
BACKGROUND: Indeterminate pulmonary nodules (IPNs) are commonly biopsied to ascertain a diagnosis of lung cancer, but many are ultimately benign. The Lung Cancer Prediction (LCP) score is a commercially available deep learning radiomic model with str...
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