Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network.

Journal: Annals of surgical oncology
PMID: 38700799

Abstract

BACKGROUND: Rectal tumors display varying degrees of response to total neoadjuvant therapy (TNT). We evaluated the performance of a convolutional neural network (CNN) in interpreting endoscopic images of either a non-complete response to TNT or local regrowth during watch-and-wait surveillance.

Authors

  • Hannah Williams
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hannah M Thompson
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Christina Lee
    Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Aneesh Rangnekar
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Jorge T Gomez
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Maria Widmar
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Iris H Wei
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Emmanouil P Pappou
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Garrett M Nash
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Martin R Weiser
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Philip B Paty
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • J Joshua Smith
    Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Harini Veeraraghavan
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY; veerarah@mskcc.org.
  • Julio Garcia-Aguilar
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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