Precision Drug Repurposing: A Deep Learning Toolkit for Identifying 34 Hyperpigmentation-Associated Genes and Optimizing Treatment Selection.

Journal: Annals of plastic surgery
PMID: 38896860

Abstract

BACKGROUND: Hyperpigmentation is a skin disorder characterized by a localized darkening of the skin due to increased melanin production. When patients fail first line topical treatments, secondary treatments such as chemical peels and lasers are offered. However, these interventions are not devoid of risks and are associated with postinflammatory hyperpigmentation. In the quest for novel therapeutic potentials, this study aims to investigate computational methods in the identification of new targeted therapies in the treatment of hyperpigmentation.

Authors

  • Shuwei Chen
    From the Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Junhao Zeng
    From the Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Mariam Saad
    Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • William C Lineaweaver
  • Zhiwei Chen
    School of Life Sciences, Shandong University of Technology, Zibo 255049, PR China.
  • Yuyan Pan
    From the Department of Plastic Surgery, Zhongshan Hospital.

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