AIMC Topic: Precision Medicine
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Advancements and challenges in pediatric dilated cardiomyopathy: a comprehensive review of current approaches and future directions.
European journal of pediatrics
Aug 12, 2025
Cardiomyopathies pose a significant risk of morbidity and mortality worldwide, with dilated cardiomyopathy (DCM) recognized as the leading cause of pediatric heart transplantation. Understanding the unique presentation of DCM in the pediatric populat...
Reframing robotics in Mohs surgery for rare cutaneous sarcomas: conceptual promise and clinical realities in precision oncology.
Journal of robotic surgery
Aug 9, 2025
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma in which achieving histologically negative margins is paramount to minimizing recurrence. Mohs micrographic surgery (MMS) has transformed margin control in DFSP by...
Optimizing Cardiovascular Risk Management in Primary Care Using a Personalized eCoach Solution Enhanced by an Artificial Intelligence-Driven Clinical Prediction Model: Protocol from the Coronary Artery Disease Risk Estimation and Early Detection Consortium.
JMIR research protocols
Aug 8, 2025
BACKGROUND: Atherosclerotic cardiovascular disease poses a heavy burden on the population's health and health care costs. Identifying apparently healthy individuals at risk of developing cardiovascular diseases using clinical prediction models raises...
Digital Twins for Personalized Medicine Require Epidemiological Data and Mathematical Modeling: Viewpoint.
Journal of medical Internet research
Aug 5, 2025
Digital twin (DT) technology is revolutionizing clinical practice by integrating diverse epidemiological data sources to create dynamic, patient-specific simulations. By leveraging data from genomics, proteomics, imaging, sociodemographics, and real-...
Personalized colorectal cancer risk assessment through explainable AI and Gut microbiome profiling.
Gut microbes
Aug 4, 2025
The clinical adenoma - carcinoma progression represents a well-established framework for understanding colorectal cancer (CRC) development, although the molecular mechanisms underlying this transition remain only partially understood. Increasing evid...
A multimodal dataset for precision oncology in head and neck cancer.
Nature communications
Aug 4, 2025
Head and neck cancer is a common disease and is associated with a poor prognosis. A promising approach to improving patient outcomes is personalized treatment, which uses information from a variety of modalities. However, only little progress has bee...
Personalizing cancer therapy: the role of pharmacogenetics in overcoming drug resistance and toxicity.
Molecular biology reports
Aug 2, 2025
Cancer pharmacogenetics has become a cornerstone of precision oncology. It offers the potential to optimize therapeutic outcomes by tailoring treatments to individual genetic profiles. This review explores the central role of pharmacogenomics in addr...
Exploring doctors' perspectives on precision medicine and AI in colorectal cancer: opportunities and challenges for the doctor-patient relationship.
BMC medical informatics and decision making
Jul 30, 2025
BACKGROUND: Precision medicine and artificial intelligence (AI) are increasingly integrated into colorectal cancer (CRC) care, offering personalised treatment strategies and data-driven decision support. While these technologies promise improved outc...
Exploring Gender Bias in AI for Personalized Medicine: Focus Group Study With Trans Community Members.
Journal of medical Internet research
Jul 29, 2025
BACKGROUND: This paper explores the perception and application of artificial intelligence (AI) for personalized medicine within the trans community, an often-overlooked demographic in the broader scope of precision medicine. Despite growing advanceme...
Explainable deep learning for stratified medicine in inflammatory bowel disease.
Genome biology
Jul 24, 2025
Moving from a one-size-fits-all to an individual approach in precision medicine requires a deeper understanding of disease molecular mechanisms. Especially in heterogeneous complex diseases such as inflammatory bowel disease (IBD), better molecular s...
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