Risk prediction of cholangitis after stent implantation based on machine learning.

Journal: Scientific reports
PMID:

Abstract

The risk of cholangitis after ERCP implantation in malignant obstructive jaundice patients remains unknown. To develop models based on artificial intelligence methods to predict cholangitis risk more accurately, according to patients after stent implantation in patients' MOJ clinical data. This retrospective study included 218 patients with MOJ undergoing ERCP surgery. A total of 27 clinical variables were collected as input variables. Seven models (including univariate analysis and six machine learning models) were trained and tested for classified prediction. The model' performance was measured by AUROC. The RFT model demonstrated excellent performances with accuracies up to 0.86 and AUROC up to 0.87. Feature selection in RF and SHAP was similar, and the choice of the best variable subset produced a high performance with an AUROC up to 0.89. We have developed a hybrid machine learning model with better predictive performance than traditional LR prediction models, as well as other machine learning models for cholangitis based on simple clinical data. The model can assist doctors in clinical diagnosis, adopt reasonable treatment plans, and improve the survival rate of patients.

Authors

  • Rui Zhao
  • Lin Gu
  • Xiquan Ke
    The First Affiliated Hospital of Bengbu Medical University, Yanhuai Road, Bengbu, 233000, China.
  • Xiaojing Deng
    The First Affiliated Hospital of Bengbu Medical University, Yanhuai Road, Bengbu, 233000, China.
  • Dapeng Li
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China.
  • Zhenzeng Ma
    The First Affiliated Hospital of Bengbu Medical University, Yanhuai Road, Bengbu, 233000, China.
  • Qizhi Wang
    The First Affiliated Hospital of Bengbu Medical University, Yanhuai Road, Bengbu, 233000, China.
  • Hailun Zheng
    The First Affiliated Hospital of Bengbu Medical University, Yanhuai Road, Bengbu, 233000, China. 7369102@qq.com.
  • Yong Yang
    Department of Radiation Oncology, Stanford University, CA, USA.