A machine learning contest enhances automated freezing of gait detection and reveals time-of-day effects.

Journal: Nature communications
Published Date:

Abstract

Freezing of gait (FOG) is a debilitating problem that markedly impairs the mobility and independence of 38-65% of people with Parkinson's disease. During a FOG episode, patients report that their feet are suddenly and inexplicably "glued" to the floor. The lack of a widely applicable, objective FOG detection method obstructs research and treatment. To address this problem, we organized a 3-month machine-learning contest, inviting experts from around the world to develop wearable sensor-based FOG detection algorithms. 1,379 teams from 83 countries submitted 24,862 solutions. The winning solutions demonstrated high accuracy, high specificity, and good precision in FOG detection, with strong correlations to gold-standard references. When applied to continuous 24/7 data, the solutions revealed previously unobserved patterns in daily living FOG occurrences. This successful endeavor underscores the potential of machine learning contests to rapidly engage AI experts in addressing critical medical challenges and provides a promising means for objective FOG quantification.

Authors

  • Amit Salomon
    Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel.
  • Eran Gazit
    Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo 6492416, Israel.
  • Pieter Ginis
  • Baurzhan Urazalinov
  • Hirokazu Takoi
  • Taiki Yamaguchi
    Preferred Networks, Inc., 100-0004, 1-6-1 Otemachi, Chiyoda-ku, Tokyo, Japan.
  • Shuhei Goda
  • David Lander
  • Julien Lacombe
  • Aditya Kumar Sinha
  • Alice Nieuwboer
    Research Group for Neurorehabilitation (eNRGy), Department of Rehabilitation Sciences, KU Leuven, Tervuursevest 101, 3001 Heverlee, Belgium.
  • Leslie C Kirsch
    Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
  • Ryan Holbrook
    Kaggle, San Francisco, CA, USA.
  • Brad Manor
    Harvard Medical School, Boston, MA 02115, USA.
  • Jeffrey M Hausdorff
    The Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.