Mass Spectrometric and Artificial Intelligence-Based Identification of the Secretome of Plasmodium falciparum Merozoites to Provide Novel Candidates for Vaccine Development Pipeline.

Journal: Proteomics. Clinical applications
PMID: 39082488

Abstract

PURPOSE: Merozoites are the only extracellular form of blood stage parasites, making it a worthwhile target. Multiple invasins that are stored in the merozoite apical organelles, are secreted just prior to invasion, and mediates its interaction with RBC. A comprehensive identification of all these secreted invasins is lacking and this study addresses that gap.

Authors

  • Akshay Munjal
    Special Centre of Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
  • Devasahayam Arokia Balaya Rex
    Centre for Integrative Omics Data Science, Yenepoya (Deemed to be University), Derlakatte, Mangalore, India.
  • Prachi Garg
    Special Centre of Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
  • Thottethodi Subrahmanya Keshava Prasad
    Centre for Systems Biology and Molecular Medicine (CSBMM), Yenepoya (Deemed to Be University), Manglore, Karnataka, India.
  • Sai Kumar Mishra
    Center for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Noida, Uttar Pradesh, India.
  • Yuktika Malhotra
    Center for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Noida, Uttar Pradesh, India.
  • Deepika Yadav
    Center for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Noida, Uttar Pradesh, India.
  • Jerry John
    Center for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Noida, Uttar Pradesh, India.
  • Preeti P
    Center for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Noida, Uttar Pradesh, India.
  • Kamal Rawal
    Centre for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.
  • Shailja Singh
    Special Centre of Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.

Keywords

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