AIMC Topic: Mass Spectrometry
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A novel UHPLC-HRMS method for simultaneous determination of 20 amino metabolites and proteins in lymphoma patients' cells and serum.
Scientific reports
Jul 1, 2025
Highly sensitive and selective monitoring of amino metabolites such as glutamine, arginine, tryptophan and related proteins played significant roles in early diagnosis and warning of lymphoma. But those limited abundance and lacked chromophore group ...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.
Nature communications
Jul 1, 2025
Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies i...
Evaluation of normalization strategies for mass spectrometry-based multi-omics datasets.
Metabolomics : Official journal of the Metabolomic Society
Jul 1, 2025
INTRODUCTION: Data normalization is crucial for multi-omics integration, reducing systematic errors and maximizing the likelihood of discovering true biological variation. Most studies assess normalization for a single omics type or use datasets from...
Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry.
BMJ open respiratory research
Jun 27, 2025
INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibili...
Robust Multiclass Feature Selection for the Authentication of Honey Botanical Origin via Nontargeted LC-MS Analysis.
Analytical chemistry
Jun 11, 2025
Honey is one of the most frequently frauded foods due to the high market price of certain kinds of monofloral honey. Traditional authentication methods involving pollen or targeted analysis have limitations that can be manipulated by fraudsters. Nont...
Insights Powered by Artificial Intelligence: Analyzing the Extent of Method Validation in Pesticide Residue Literature.
Journal of agricultural and food chemistry
Jun 6, 2025
Validation of analytical methods to assess figures of merit and other key performance parameters is a fundamental requirement within the fitness-for-purpose concept. By combining generative AI and subject matter review, this perspective article provi...
A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy.
Nature communications
May 30, 2025
Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and d...
AI-powered insights into the UniSpray ionization in supercritical fluid chromatography-mass spectrometry.
Journal of chromatography. A
May 16, 2025
Selection of the optimal makeup solvent composition is critical for achieving sensitive and reproducible ionization in supercritical fluid chromatography-mass spectrometry (SFC-MS). This study investigated the ionization processes in a spray-based io...
Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.
Cell reports. Medicine
Apr 30, 2025
The lack of reliable non-invasive biomarkers for early colorectal cancer (CRC) diagnosis underscores the need for improved diagnostic tools. Extracellular vesicles (EVs) have emerged as promising candidates for liquid-biopsy-based cancer monitoring. ...
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