Understanding natural language: Potential application of large language models to ophthalmology.

Journal: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
Published Date:

Abstract

Large language models (LLMs), a natural language processing technology based on deep learning, are currently in the spotlight. These models closely mimic natural language comprehension and generation. Their evolution has undergone several waves of innovation similar to convolutional neural networks. The transformer architecture advancement in generative artificial intelligence marks a monumental leap beyond early-stage pattern recognition via supervised learning. With the expansion of parameters and training data (terabytes), LLMs unveil remarkable human interactivity, encompassing capabilities such as memory retention and comprehension. These advances make LLMs particularly well-suited for roles in healthcare communication between medical practitioners and patients. In this comprehensive review, we discuss the trajectory of LLMs and their potential implications for clinicians and patients. For clinicians, LLMs can be used for automated medical documentation, and given better inputs and extensive validation, LLMs may be able to autonomously diagnose and treat in the future. For patient care, LLMs can be used for triage suggestions, summarization of medical documents, explanation of a patient's condition, and customizing patient education materials tailored to their comprehension level. The limitations of LLMs and possible solutions for real-world use are also presented. Given the rapid advancements in this area, this review attempts to briefly cover many roles that LLMs may play in the ophthalmic space, with a focus on improving the quality of healthcare delivery.

Authors

  • Zefeng Yang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
  • Deming Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
  • Fengqi Zhou
    Ophthalmology, Mayo Clinic Health System, Eau Claire, Wisconsin, USA.
  • Diping Song
    ShenZhen Key Lab of Computer Vision and Pattern Recognition, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People's Republic of China; University of Chinese Academy of Sciences, Beijing, People's Republic of China.
  • Yinhang Zhang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
  • Jiaxuan Jiang
  • Kangjie Kong
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
  • Xiaoyi Liu
    Computer Science and Engineering, University of South Carolina, Columbia 29208, USA.
  • Yu Qiao
    Department of English and American Studies, RWTH Aachen University, Aachen, North Rhine-Westphalia, Germany.
  • Robert T Chang
    Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California.
  • Ying Han
    Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
  • Fei Li
    Institute for Precision Medicine, Tsinghua University, Beijing, China.
  • Clement C Tham
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Hong Kong Eye Hospital, Hong Kong Special Administrative Region, China; Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
  • Xiulan Zhang
    Zhongshan Ophthalmic Center, Sun Yat-sen University, China. Electronic address: zhangxl2@mail.sysu.edu.cn.