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Aurora Kinase A

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Ligand-based pharmacophore modeling and machine learning for the discovery of potent aurora A kinase inhibitory leads of novel chemotypes.

Molecular diversity 38446372
Aurora-A (AURKA) is serine/threonine protein kinase involved in the regulation of numerous processes of cell division. Numerous studies have demonstrated strong association between AURKA and cancer. AURKA is overexpressed in many cancers, such as col...
Aurora Kinase A Drug Discovery Humans Ligands Machine Learning Models, Molecular Pharmacophore Protein Kinase Inhibitors Quantitative Structure-Activity Relationship
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