AIMC Topic: Biomolecular Condensates

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A two-task predictor for discovering phase separation proteins and their undergoing mechanism.

Briefings in bioinformatics
Liquid-liquid phase separation (LLPS) is one of the mechanisms mediating the compartmentalization of macromolecules (proteins and nucleic acids) in cells, forming biomolecular condensates or membraneless organelles. Consequently, the systematic ident...

Predicting protein condensate formation using machine learning.

Cell reports
Membraneless organelles are liquid condensates, which form through liquid-liquid phase separation. Recent advances show that phase separation is essential for cellular homeostasis by regulating basic cellular processes, including transcription and si...