AIMC Topic: Biomolecular Condensates
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PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms.
Nature communications
Dec 11, 2024
Biomolecular condensates are membraneless organelles that can concentrate hundreds of different proteins in cells to operate essential biological functions. However, accurate identification of their components remains challenging and biased towards p...
Protein Condensate Atlas from predictive models of heteromolecular condensate composition.
Nature communications
Jul 10, 2024
Biomolecular condensates help cells organise their content in space and time. Cells harbour a variety of condensate types with diverse composition and many are likely yet to be discovered. Here, we develop a methodology to predict the composition of ...
Molecular Graph-Based Deep Learning Algorithm Facilitates an Imaging-Based Strategy for Rapid Discovery of Small Molecules Modulating Biomolecular Condensates.
Journal of medicinal chemistry
Nov 8, 2023
Biomolecular condensates are proposed to cause diseases, such as cancer and neurodegeneration, by concentrating proteins at abnormal subcellular loci. Imaging-based compound screens have been used to identify small molecules that reverse or promote b...
Distinct chemical environments in biomolecular condensates.
Nature chemical biology
Sep 28, 2023
Diverse mechanisms have been described for selective enrichment of biomolecules in membrane-bound organelles, but less is known about mechanisms by which molecules are selectively incorporated into biomolecular assemblies such as condensates that lac...
Screening membraneless organelle participants with machine-learning models that integrate multimodal features.
Proceedings of the National Academy of Sciences of the United States of America
Jun 10, 2022
Protein self-assembly is one of the formation mechanisms of biomolecular condensates. However, most phase-separating systems (PS) demand multiple partners in biological conditions. In this study, we divided PS proteins into two groups according to th...
Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography.
Proceedings of the National Academy of Sciences of the United States of America
May 13, 2025
Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficulties in visualizing the condensate interior at hig...
A two-task predictor for discovering phase separation proteins and their undergoing mechanism.
Briefings in bioinformatics
Sep 23, 2024
Liquid-liquid phase separation (LLPS) is one of the mechanisms mediating the compartmentalization of macromolecules (proteins and nucleic acids) in cells, forming biomolecular condensates or membraneless organelles. Consequently, the systematic ident...
Predicting protein condensate formation using machine learning.
Cell reports
Feb 2, 2021
Membraneless organelles are liquid condensates, which form through liquid-liquid phase separation. Recent advances show that phase separation is essential for cellular homeostasis by regulating basic cellular processes, including transcription and si...
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