AIMC Topic: Clonal Hematopoiesis
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Gene-Specific Machine Learning Models to Classify Driver Mutations in Clonal Hematopoiesis.
Cancer discovery
Sep 4, 2024
There is no general consensus on the set of mutations capable of driving the age-related clonal expansions in hematopoietic stem cells known as clonal hematopoiesis, and current variant classifications typically rely on rules derived from expert know...
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis.
Cancer discovery
Sep 4, 2024
Clonal hematopoiesis (CH) is a phenomenon of clonal expansion of hematopoietic stem cells driven by somatic mutations affecting certain genes. Recently, CH has been linked to the development of hematologic malignancies, cardiovascular diseases, and o...
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