AIMC Topic: Proguanil

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Application of molecular docking and PSO-SVR intelligent approaches in antimalarial activity prediction of enantiomeric cycloguanil analogues.

SAR and QSAR in environmental research Nov 1, 2018
A series of antifolate compounds, i.e. 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine, or cycloguanil analogues, have shown effective inhibiting properties against Plasmodium falciparum dihydrofolate reductase (PfDHFR). In this work, the ...
Machine Learning Algorithms Reproducibility of Results Molecular Docking Simulation Protein Binding Plasmodium falciparum Molecular Structure Antimalarials Enzyme Inhibitors Quantitative Structure-Activity Relationship Stereoisomerism Folic Acid Antagonists Substrate Specificity Triazines Proguanil Tetrahydrofolate Dehydrogenase
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