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Folic Acid Antagonists

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Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe.

Diagnostic microbiology and infectious disease 29306582
Iclaprim is a diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and it is highly active against Gram-positive pathogens including emerging drug-resistant pathogens. In vitro activity of iclaprim and comparators against 2814 Gram-po...
Americas Anti-Bacterial Agents Asia Europe Folic Acid Antagonists Gram-Positive Bacterial Infections Humans Microbial Sensitivity Tests Pyrimidines Staphylococcus aureus Streptococcus
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Application of molecular docking and PSO-SVR intelligent approaches in antimalarial activity prediction of enantiomeric cycloguanil analogues.

SAR and QSAR in environmental research 30381963
A series of antifolate compounds, i.e. 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine, or cycloguanil analogues, have shown effective inhibiting properties against Plasmodium falciparum dihydrofolate reductase (PfDHFR). In this work, the ...
Algorithms Antimalarials Enzyme Inhibitors Folic Acid Antagonists Machine Learning Molecular Docking Simulation Molecular Structure Plasmodium falciparum Proguanil Protein Binding Quantitative Structure-Activity Relationship Reproducibility of Results Stereoisomerism Substrate Specificity Tetrahydrofolate Dehydrogenase Triazines
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Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics 33879017
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...
Aminopyridines Antifungal Agents Benzodioxoles Candida albicans Candidiasis Cyclopropanes Deep Learning Drug Approval Drug Repositioning Folic Acid Antagonists Humans Lactams, Macrocyclic Molecular Docking Simulation Molecular Dynamics Simulation Proline Rifampin Sulfonamides Tetrahydrofolate Dehydrogenase United States United States Food and Drug Administration
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