AIMC Topic: Folic Acid Antagonists

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Deep-learning based repurposing of FDA-approved drugs against dihydrofolate reductase and molecular dynamics study.

Journal of biomolecular structure & dynamics Apr 21, 2021
causes the fatal fungal bloodstream infection in humans called Candidiasis. Most of the species are resistant to the antifungals used to treat them. Drug-resistant poses very serious public health issues. To overcome this, the development of effec...
Humans Molecular Docking Simulation Deep Learning United States Candida albicans Cyclopropanes Drug Repositioning Candidiasis Antifungal Agents Molecular Dynamics Simulation Sulfonamides United States Food and Drug Administration Proline Lactams, Macrocyclic Drug Approval Rifampin Folic Acid Antagonists Aminopyridines Tetrahydrofolate Dehydrogenase Benzodioxoles
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Application of molecular docking and PSO-SVR intelligent approaches in antimalarial activity prediction of enantiomeric cycloguanil analogues.

SAR and QSAR in environmental research Nov 1, 2018
A series of antifolate compounds, i.e. 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine, or cycloguanil analogues, have shown effective inhibiting properties against Plasmodium falciparum dihydrofolate reductase (PfDHFR). In this work, the ...
Machine Learning Algorithms Reproducibility of Results Molecular Docking Simulation Protein Binding Plasmodium falciparum Molecular Structure Antimalarials Enzyme Inhibitors Quantitative Structure-Activity Relationship Stereoisomerism Folic Acid Antagonists Substrate Specificity Triazines Proguanil Tetrahydrofolate Dehydrogenase
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Surveillance of iclaprim activity: In vitro susceptibility of gram-positive pathogens collected from 2012 to 2014 from the United States, Asia Pacific, Latin American and Europe.

Diagnostic microbiology and infectious disease Dec 7, 2017
Iclaprim is a diaminopyrimidine, which inhibits bacterial dihydrofolate reductase, and it is highly active against Gram-positive pathogens including emerging drug-resistant pathogens. In vitro activity of iclaprim and comparators against 2814 Gram-po...
Humans Anti-Bacterial Agents Microbial Sensitivity Tests Staphylococcus aureus Europe Gram-Positive Bacterial Infections Pyrimidines Americas Asia Folic Acid Antagonists Streptococcus
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