Recent advancements in microbiome research have revealed the restorative capacities of postbiotics, including indole and its derivatives generated via bacterial tryptophan metabolism. Widespread in prokaryotic and eukaryotic communities, indole and i... read more
OBJECTIVES: To evaluate the performance of Claude 3.7 Sonnet in automating data extraction for systematic literature reviews (SLRs). METHODS: An artificial intelligence (AI) extraction model based on the Claude 3.7 Sonnet large language model was dev... read more
RATIONALE AND OBJECTIVES: Large language models (LLMs) are increasingly investigated in radiology education. This study evaluated the performance of several advanced LLMs on radiology residency in-training examination questions, with a focus on wheth... read more
BACKGROUND: The American Academy of Ophthalmology recommendations on screening for hydroxychloroquine (HCQ) retinopathy are now a decade old. This revision provides an update based on current knowledge. Major points and changes are as follows. NATURE... read more
BACKGROUND: Depression presents with heterogeneity in symptom trajectories, complicating individualized treatment. Identifying distinct classes of symptom trajectories and their predictors may enable earlier intervention for those at greatest risk of... read more
BACKGROUND: Sex-related differences in coronary artery disease (CAD) burden and outcomes are increasingly recognized but not fully understood, particularly when assessed using advanced imaging techniques. OBJECTIVES: To investigate sex differences in... read more
Single-cell multimodal analysis based on machine learning integrates data from multiple modalities such as cell morphological features, gene expression, proteomics, and metabolomics and observes single cells from multiple dimensions. This multi-dimen... read more
This comprehensive review focuses on the use of knowledge graphs and Graph Neural Networks (GNNs) to integrate multi-omics data in the field of personalized nutrition. It investigates how different biological datasets-like genomics, proteomics, metab... read more
Gene sequence prediction not only effectively identifies homologous genes but also provides crucial insights into gene function and evolutionary relationships, making it one of the significant research directions in the field of bioinformatics. Given... read more
Journal of pharmaceutical and biomedical analysis
Nov 11, 2025
Monitoring of metabolite dynamics during cell culture process is crucial for ensuring consistent monoclonal antibody (mAb) yield and quality. While proton nuclear magnetic resonance (1H NMR) offers an ideal solution for process monitoring due to its ... read more
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