Artificial Intelligence Medical Compendium

Rapid progress in artificial intelligence (AI) capabilities has drawn fresh attention to the prospect of consciousness in AI. There is an urgent need for rigorous methods to assess AI systems for consciousness, but significant uncertainty about relev... read more 

BACKGROUND: The risk of depression is significantly elevated in middle-aged and older adults with insomnia; however, the pathways between mild and severe insomnia are different. Most existing prediction tools treat insomnia as a single construct, ign... read more 

BACKGROUND: Major depressive disorder (MDD) is a leading cause of disability worldwide, yet antidepressant response remains highly variable, with many patients failing to achieve remission. Resting-state functional connectivity (RSFC) studies have li... read more 

INTRODUCTION: MRI compatible EEG systems enable simultaneous EEG-fMRI data assessment, which provides high spatial and high temporal resolution of neural signaling data. Functional connectivity analyses suggest altered fronto-limbic emotion regulatio... read more 

BACKGROUND: Adherence to oral anticoagulants (OACs) for atrial fibrillation (AF) stroke prevention is traditionally defined as taking 80% of doses as prescribed, but this threshold has not been clinically validated. OBJECTIVES: We identified OAC adhe... read more 

Indomethacin (IND) is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties, and is widely used for the treatment of diverse inflammatory diseases. However, its poor aqueous solubility severely li... read more 

Amyotrophic lateral sclerosis (ALS) requires precise therapeutic monitoring of Edaravone, but current methods lack real-time capability. Herein, we developed a photoelectrochemical (PEC) sensor using a Bi4Ti3O12/BiOBr heterojunction for ultrasensitiv... read more 

BACKGROUND: White blood cells (WBCs) are vital components of the immune system, and accurate detection and classification are essential for diagnosing and monitoring various diseases. Traditional microscopic detection methods require expensive equipm... read more 

Celecoxib (CXB) is a non-steroidal anti-inflammatory drug used to prevent and treat arthritis. However, overdosing or improper use can cause adverse reactions. SERS is an important tool for therapeutic drug monitoring (TDM).The present study proposes... read more 

The CRISPR/Cas9 system is a powerful gene-editing tool. Its specificity and stability rely on complex allosteric regulation. Understanding these allosteric regulations is essential for developing high-fidelity Cas9 variants with reduced off-target ef... read more