Hemoglobin-based oxygen carriers promote systemic hyperfibrinolysis that is both dependent and independent of plasmin.

Journal: The Journal of surgical research
PMID: 28601310

Abstract

BACKGROUND: Hyperfibrinolysis plays an integral role in the genesis of trauma-induced coagulopathy. Recent data demonstrate that red blood cell lysis promotes fibrinolysis; however, the mechanism is unclear. Hemoglobin-based oxygen carriers (HBOCs) have been developed for resuscitation and have been associated with coagulopathy. We hypothesize that replacement of whole blood (WB) using an HBOC results in a coagulopathy because of the presence of free hemoglobin.

Authors

  • Alexander P Morton
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado. Electronic address: alexander.morton@ucdenver.edu.
  • Ernest E Moore
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado; Department of Surgery-Denver Health Medical Center, Denver, Colorado.
  • Hunter B Moore
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado.
  • Eduardo Gonzalez
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado.
  • Michael P Chapman
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado.
  • Erik Peltz
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado.
  • Anirban Banerjee
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado.
  • Christopher Silliman
    Department of Surgery-Trauma Research Center, University of Colorado, Denver, Colorado; Bonfils Blood Center, Denver, Colorado.

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