Exploring explainable AI features in the vocal biomarkers of lung disease.

Journal: Computers in biology and medicine
Published Date:

Abstract

This review delves into the burgeoning field of explainable artificial intelligence (XAI) in the detection and analysis of lung diseases through vocal biomarkers. Lung diseases, often elusive in their early stages, pose a significant public health challenge. Recent advancements in AI have ushered in innovative methods for early detection, yet the black-box nature of many AI models limits their clinical applicability. XAI emerges as a pivotal tool, enhancing transparency and interpretability in AI-driven diagnostics. This review synthesizes current research on the application of XAI in analyzing vocal biomarkers for lung diseases, highlighting how these techniques elucidate the connections between specific vocal features and lung pathology. We critically examine the methodologies employed, the types of lung diseases studied, and the performance of various XAI models. The potential for XAI to aid in early detection, monitor disease progression, and personalize treatment strategies in pulmonary medicine is emphasized. Furthermore, this review identifies current challenges, including data heterogeneity and model generalizability, and proposes future directions for research. By offering a comprehensive analysis of explainable AI features in the context of lung disease detection, this review aims to bridge the gap between advanced computational approaches and clinical practice, paving the way for more transparent, reliable, and effective diagnostic tools.

Authors

  • Zhao Chen
  • Ning Liang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Haoyuan Li
    School of Computer Science, Yangtze University, Jingzhou, Hubei Province, China.
  • Haili Zhang
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Huizhen Li
    Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China.
  • Lijiao Yan
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Ziteng Hu
    Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Yaxin Chen
    Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China.
  • Yujing Zhang
    Bradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.
  • Yanping Wang
    The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
  • Dandan Ke
    Special Disease Clinic, Huaishuling Branch of Beijing Fengtai Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China. Electronic address: kedandan1987@163.com.
  • Nannan Shi
    Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.