Investigation of ferroptosis-associated molecular subtypes and immunological characteristics in lupus nephritis based on artificial neural network learning.

Journal: Arthritis research & therapy
Published Date: Jul 3, 2024

Abstract

BACKGROUND: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) with poor treatment outcomes. The role and underlying mechanisms of ferroptosis in LN remain largely unknown. We aimed to explore ferroptosis-related molecular subtypes and assess their prognostic value in LN patients.

Authors

  • Li Zhang
    Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
  • Qing Yan
    Department of Electrical Engineering and Automation, Anhui University, Hefei 230601, China. Electronic address: anhuixbt@sina.com.
  • Miao Lin
    Second Department of General Surgery, The People's Hospital of Yuhuan, Yuhuan, Zhejiang, China (M.L.).
  • Juanjuan He
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai Neurosurgical Clinical Center, Shanghai, China.
  • Jie Tian
    CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Zhihan Chen
    Department of Rheumatology and Immunology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 134 Dongjie Road, Fuzhou, 350001, Fujian Province, China. zhihanchen213@163.com.
  • Fuyuan Hong
    Department of Nephrology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, PR China. hongdoc@163.com.

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