AIMC Topic: Ferroptosis
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Ferroptosis-related hub genes and immune cell dynamics as diagnostic biomarkers in age-related macular degeneration.
European journal of medical research
Aug 20, 2025
BACKGROUND: Age-related Macular Degeneration (AMD) is widely acknowledged as a principal cause of vision loss in the elderly. Currently, the therapeutic interventions available in clinical practice fail to achieve satisfactory outcomes. Therefore, it...
Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network.
Scientific reports
Aug 6, 2025
Lung adenocarcinoma (LUAD), the most common non-small cell lung cancer subtype, often presents with subtle early symptoms leading to delayed diagnosis. Ferroptosis, a cell death process associated with iron metabolism dysregulation, has been linked t...
Machine learning identification of key genes in cardioembolic stroke and atherosclerosis: their association with pan-cancer and immune cells.
European journal of medical research
Jul 24, 2025
BACKGROUND: Cardioembolic stroke (CS) and atherosclerosis (AS) are closely related diseases. Ferroptosis, a novel form of programmed cell death, may play a key role in CS and AS. However, the pathophysiological mechanisms underlying their coexistence...
Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer.
Biology direct
Jul 21, 2025
BACKGROUND: Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence on colorectal cancer (CRC) p...
Combination of machine learning and protein‑protein interaction network established one ATM‑DPP4‑TXN ferroptotic diagnostic model with experimental validation.
Molecular medicine reports
Jul 4, 2025
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
LncRNAs regulates cell death in osteosarcoma.
Scientific reports
Jul 2, 2025
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Iron metabolism and preeclampsia: new insights from bioinformatics analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jul 1, 2025
OBJECTIVE: Preeclampsia (PE) is a multifactorial systemic pregnancy disease, in which iron metabolism and ferroptosis play significant roles during its pathogenesis. The diagnosis and prevention of PE remain urgent clinical issues that need to be add...
Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis.
Frontiers in immunology
May 16, 2025
BACKGROUND: Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulatio...
Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis.
International journal of molecular sciences
May 1, 2025
Peri-implantitis (PI) is a chronic inflammatory disease that ultimately leads to the dysfunction and loss of implants with established osseointegration. Ferroptosis has been implicated in the progression of PI, but its precise mechanisms remain uncle...
Identification of biomarkers related to iron death in diabetic kidney disease based on machine learning algorithms.
Annals of human biology
Apr 2, 2025
BACKGROUND: While ferroptosis has been recognised for its key role in tumour development, its involvement in DKD is not well understood. Identifying differentially expressed ferroptosis-related genes (DEIRGs) could help improve early diagnosis and tr...
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