Causal Deep Learning for the Detection of Adverse Drug Reactions: Drug-Induced Acute Kidney Injury as a Case Study.

Journal: Studies in health technology and informatics
PMID:

Abstract

Causal Deep/Machine Learning (CDL/CML) is an emerging Artificial Intelligence (AI) paradigm. The combination of causal inference and AI could mine explainable causal relationships between data features, providing useful insights for various applications, e.g. Pharmacovigilance (PV) signal detection upon Real-World Data. The objective of this study is to demonstrate the use of CDL for potential PV signal validation using Electronic Health Records as input data source.

Authors

  • Stella Dimitsaki
    Institute of Applied Biosciences, Centre for Research & Technology Hellas, Thermi, Thessaloniki, Greece. Electronic address: sdimitsaki@certh.gr.
  • Pantelis Natsiavas
  • Marie-Christine Jaulent
    INSERM UMRS 1142, Medicine Faculty, Pierre and Marie Curie University, Sorbonne Universities, Paris, France.