Identification of COL3A1 as a candidate protein involved in the crosstalk between obesity and diarrhea using quantitative proteomics and machine learning.

Journal: European journal of pharmacology
PMID:

Abstract

BACKGROUND: Increasing epidemiologic studies have shown a positive correlation between obesity and chronic diarrhea. Nevertheless, the precise etiology remains uncertain.

Authors

  • Yan Wang
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Xiangyao Wang
    Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
  • Xiaotong Niu
    Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China; Medical School of Chinese PLA, Beijing, 100853, China.
  • Ke Han
    School of Computer and Information Engineering, Harbin University of Commerce, Harbin 150040, China. hanke@hrbcu.edu.cn.
  • Nan Ru
    Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China.
  • Jingyuan Xiang
    Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China; Medical School of Chinese PLA, Beijing, 100853, China.
  • Enqiang Linghu
    Nankai University School of Medicine, Nankai University, Tianjin, 300071, China; Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China. Electronic address: linghuenqiang@vip.sina.com.