AIMC Topic: Case-Control Studies
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Development of an electronic health record-based Human Immunodeficiency Virus (HIV) risk prediction model for women, incorporating social determinants of health.
BMC public health
Jul 2, 2025
BACKGROUND: Human Immunodeficiency Virus (HIV) pre-exposure prophylaxis (PrEP) prevents HIV transmission but has low uptake among women. Identifying women who could benefit from PrEP remains a challenge. This study developed a women-specific model to...
Metabolomic biomarkers could be molecular clocks in timing stroke onset.
Scientific reports
Jul 1, 2025
The preferred treatment for acute ischaemic stroke (AIS) is intravenous thrombolysis (IVT) administered within 4.5 hours (h) of symptom onset. This study aimed to identify metabolomic biomarkers for distinguishing AIS patients within 4.5 h of symptom...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.
Nature communications
Jul 1, 2025
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...
Machine learning analysis of kinematic movement features during functional tasks to discriminate chronic neck pain patients from asymptomatic controls.
Scientific reports
Jul 1, 2025
This study evaluated the discriminative potential of a machine learning model using movement features during functional tasks to distinguish between patients with non-traumatic chronic neck pain and asymptomatic controls. The study included patients ...
Identifying ovarian cancer with machine learning DNA methylation pattern analysis.
Scientific reports
Jul 1, 2025
The majority of patients with epithelial ovarian cancer (EOC) continue to be diagnosed at an advanced stage despite great advances in this disease treatment. To impact overall survival, we need better methods of EOC early diagnosis. We performed a ca...
Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.
Scientific reports
Jul 1, 2025
This study aimed to investigate the functionality of the prefrontal cortex in patients with unipolar depression (UD) and bipolar depression (BD) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT). Additionally, it ...
Harnessing artificial intelligence for detection of pancreatic cancer: a machine learning approach.
Clinical and experimental medicine
Jul 1, 2025
PURPOSE: Pancreatic cancer (PC) is one of the most lethal malignancies, often presenting with nonspecific symptoms and a dismal prognosis. Despite advancements in treatments, the 5-year survival rate remains low, highlighting the urgent need for effe...
Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry.
BMJ open respiratory research
Jun 27, 2025
INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibili...
The early prediction of neonatal necrotizing enterocolitis in high-risk newborns based on two medical center clinical databases.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jun 23, 2025
: Early identification and timely preventive interventions play an essential role for improving the prognosis of newborns with necrotizing enterocolitis (NEC). Thus, establishing a novel and simple prediction model is of great clinical significance. ...
Predicting Early-Onset Colorectal Cancer in Individuals Below Screening Age Using Machine Learning and Real-World Data: Case Control Study.
JMIR cancer
Jun 19, 2025
BACKGROUND: Colorectal cancer is now the leading cause of cancer-related deaths among young Americans. Accurate early prediction and a thorough understanding of the risk factors for early-onset colorectal cancer (EOCRC) are vital for effective preven...
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