Precision HER2: a comprehensive AI system for accurate and consistent evaluation of HER2 expression in invasive breast Cancer.

Journal: BMC cancer
PMID: 39350085

Abstract

BACKGROUND: With the development of novel anti-HER2 targeted drugs, such as ADCs, it has become increasingly important to accurately interpret HER2 expression in breast cancer. Previous studies have demonstrated high intra-observer and inter-observer variabilities in evaluating HER2 staining by human eyes. There exists a strong requirement to develop artificial intelligence (AI) systems to achieve high-precision HER2 expression scoring for better clinical therapy.

Authors

  • Zhongtang Xiong
    Department of Pathology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, NO.63, Duobao Road, Guangzhou, 510150, China.
  • Kai Liu
    College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China.
  • Shaoyan Liu
    Department of Pathology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, NO.63, Duobao Road, Guangzhou, 510150, China.
  • Jiahao Feng
    Cellsvision (Guangzhou) Medical Technology Inc., People's Republic of China.
  • Jin Wang
    Cells Vision (Guangzhou) Medical Technology Inc., Guangzhou, China. Electronic address: wangjin@cellsvision.com.
  • Zewen Feng
    Department of Pathology; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, NO.63, Duobao Road, Guangzhou, 510150, China.
  • Boan Lai
    Department of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
  • Qingxin Zhang
    Department of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
  • Qingping Jiang
    Department of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.

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