AIMC Topic: Biomarkers, Tumor
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A review of the use of tumour DNA methylation for breast cancer subtyping and prediction of outcomes.
Clinical epigenetics
Jul 2, 2025
DNA methylation in breast tumours has been extensively studied and has provided valuable insights into the clinical heterogeneity of breast cancer. In this review, we summarise the current literature that has used DNA methylation markers to subtype b...
Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types.
Scientific reports
Jul 2, 2025
Breast cancer is the most prevalent and lethal form of cancer being the utmost common medical concern of women. Breast cancer etiology implicates numerous cellular protein receptors such as estrogen receptors (ER), progesterone receptors (PR), and hu...
Developing transferable and universal IR biomarkers for intraoperative colorectal cancer diagnosis via FTIR spectroscopy.
Scientific reports
Jul 2, 2025
Histological staining has long been the gold standard for cancer detection, but it is limited by subjectivity and delayed results. Fourier Transform Infrared Spectroscopy (FTIR) has emerged as a promising technique, offering the advantages of objecti...
Unveiling diagnostic biomarkers and therapeutic targets in lung adenocarcinoma using bioinformatics and experimental validation.
Scientific reports
Jul 2, 2025
Lung adenocarcinoma (LUAD) is a major challenge in oncology due to its complex molecular structure and generally poor prognosis. The aim of this study was to find diagnostic markers and therapeutic targets for LUAD by integrating differential gene ex...
Identification of exosome-related genes in NSCLC via integrated bioinformatics and machine learning analysis.
Scientific reports
Jul 2, 2025
Exosomes are crucial in the development of non-small cell lung cancer (NSCLC), yet exosome-associated genes in NSCLC remain insufficiently explored. The present study identified 59 exosome-associated differentially expressed genes (EA-DEGs) from the ...
Comprehensive machine learning analysis of PANoptosis signatures in multiple myeloma identifies prognostic and immunotherapy biomarkers.
Scientific reports
Jul 2, 2025
PANoptosis is closely associated with tumorigenesis and therapeutic response, yet its role in multiple myeloma (MM) remains unclear. This study analyzed bulk transcriptomic and clinical data from the TCGA and GEO databases to identify seven PANoptosi...
Activated cancer-associated fibroblasts correlate with poor survival and decreased lymphocyte infiltration in infiltrative type distal cholangiocarcinoma.
Scientific reports
Jul 1, 2025
Cancer-associated fibroblasts promote tumor progression through growth facilitation, invasion, and immune evasion. This study investigated the impact of activated cancer-associated fibroblasts (aCAFs) on survival outcomes, immune response, and molecu...
Decoding the diagnostic biomarkers of mitochondrial dysfunction related gene variants in pediatric T cell acute lymphoblastic leukemia.
Scientific reports
Jul 1, 2025
Mitochondrial dysfunction is crucial in the pathogenesis and drug resistance of pediatric T-cell acute lymphoblastic leukemia (T-ALL), a malignant hematological disorder with unrestrained proliferation of immature T-cells. Therefore, the primary obje...
Identification of CXCR4 as a potential preventive gene in clear cell renal cell carcinoma from machine learning and immune analysis.
Scientific reports
Jul 1, 2025
Clear cell renal cell carcinoma (ccRCC) represents a prevalent malignant kidney tumor characterized by high metastatic potential and recurrence rates. Investigations into the molecular mechanisms and therapeutic targets of ccRCC have provided novel d...
Integrated analysis of shared gene expression signatures and immune microenvironment heterogeneity in type 2 diabetes mellitus and colorectal cancer.
Scientific reports
Jul 1, 2025
Emerging evidence suggests a bidirectional relationship between colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM), yet the shared molecular mechanisms and prognostic biomarkers remain poorly characterized. This study aimed to identify novel...
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