Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients.

Journal: eLife
PMID: 39347767

Abstract

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify the particular types of lipids that are regulated as a consequence of paclitaxel administration and may be associated with the occurrence of post-therapeutic neuropathy.

Authors

  • Jörn Lötsch
    Institute of Clinical Pharmacology, Goethe - University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
  • Khayal Gasimli
    Goethe University, Department of Gynecology and Obstetrics, Frankfurt, Germany.
  • Sebastian Malkusch
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt am Main, Germany.
  • Lisa Hahnefeld
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt, Germany.
  • Carlo Angioni
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt, Germany.
  • Yannick Schreiber
    Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt, Germany.
  • Sandra Trautmann
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt, Germany.
  • Saskia Wedel
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt, Germany.
  • Dominique Thomas
    Department of Urology, Weill Cornell Medical College/New York Presbyterian, New York, NY, USA.
  • Nerea Ferreiros Bouzas
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt, Germany.
  • Christian H Brandts
    German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Benjamin Schnappauf
    Oncology Center, Sana-Klinikum Offenbach, Starkenburgring, Germany.
  • Christine Solbach
    Goethe University, Department of Gynecology and Obstetrics, Frankfurt, Germany.
  • Gerd Geisslinger
    Institute of Clinical Pharmacology, Goethe-University, Theodor Stern Kai 7, Frankfurt am Main 60590, Germany. geisslinger@em.uni-frankfurt.de.
  • Marco Sisignano
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt, Germany.

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