AIMC Topic: Paclitaxel
Clear Filters Showing 1 to 10 of 16 articles
Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data.
Computers in biology and medicine
Mar 4, 2025
Predictive biomarker identification in cancer treatment has traditionally relied on pre-defined analyses, limiting discoveries to expected biomarkers and potentially overlooking novel ones predictive of therapy response. In this work, we develop a no...
Aged
Biomarkers, Tumor
Male
Middle Aged
Lung Neoplasms
Humans
Machine Learning
Retrospective Studies
Female
Mutation
Paclitaxel
Liquid Biopsy
Clinical Trials, Phase III as Topic
Bevacizumab
Immunotherapy
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Randomized Controlled Trials as Topic
Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 10, 2025
Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-...
Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients.
eLife
Sep 30, 2024
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify th...
Noninvasive Computed Tomography-Based Deep Learning Model Predicts In Vitro Chemosensitivity Assay Results in Pancreatic Cancer.
Pancreas
Nov 24, 2023
OBJECTIVES: We aimed to predict in vitro chemosensitivity assay results from computed tomography (CT) images by applying deep learning (DL) to optimize chemotherapy for pancreatic ductal adenocarcinoma (PDAC).
Utilization of circulating cell-free DNA profiling to guide first-line chemotherapy in advanced lung squamous cell carcinoma.
Theranostics
Jan 1, 2021
Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it is still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role of circulating c...
Circulating Tumor DNA
Paclitaxel
Progression-Free Survival
Deoxycytidine
Gemcitabine
Survival Rate
Male
Middle Aged
Lung Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Treatment Outcome
Cell-Free Nucleic Acids
DNA Copy Number Variations
Cisplatin
Prognosis
Female
Carcinoma, Squamous Cell
Aged
Humans
Machine Learning
Machine Learning Methods to Extract Documentation of Breast Cancer Symptoms From Electronic Health Records.
Journal of pain and symptom management
Feb 27, 2018
CONTEXT: Clinicians document cancer patients' symptoms in free-text format within electronic health record visit notes. Although symptoms are critically important to quality of life and often herald clinical status changes, computational methods to a...
Development of a Competitive Time-Resolved Fluoroimmunoassay for Paclitaxel.
Phytochemical analysis : PCA
Dec 20, 2017
INTRODUCTION: Paclitaxel (Tax) is a diterpene alkaloid isolated from Taxus species and has proved clinically effective in treating a number of malignancies. Current quantitative analytical methods for Tax such as high-performance liquid chromatograph...
Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning.
Scientific reports
Sep 29, 2017
In the last decade, high-content screening based on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-induced phenotypic variations. Unfortunately, this method inherently requires fluorescent labeling which...
COF-1-modified magnetic nanoparticles for highly selective and efficient solid-phase microextraction of paclitaxel.
Talanta
Dec 21, 2016
Novel covalent organic framework-1 modified magnetic nanoparticles (M-COF-1) were prepared for extraction of paclitaxel from rat plasma samples. Paclitaxel is an important anti-cancer drug in clinical chemotherapy. COF-1 was immobilized on the surfac...
Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.
Lung cancer (Amsterdam, Netherlands)
Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Gefitinib
Quinazolines
Lung Neoplasms
Antineoplastic Combined Chemotherapy Protocols
Adenocarcinoma
Carcinoma, Non-Small-Cell Lung
Randomized Controlled Trials as Topic
Aged, 80 and over
Male
Middle Aged
Antineoplastic Agents
Paclitaxel
Disease-Free Survival
Smoking
Neoplasm Staging
ErbB Receptors
Humans
Mutation
Protein Kinase Inhibitors
Female
Asian People
Aged
Carboplatin
Stay Ahead of Medical AI
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 30978
- Neural Networks, Computer 29696
- Algorithms 26813
- Deep Learning 26324
- Artificial Intelligence 24267
- Robotics 13307
- Image Processing, Computer-Assisted 9512
- Retrospective Studies 9097
- Magnetic Resonance Imaging 6173
- Reproducibility of Results 5589
- Tomography, X-Ray Computed 4765
- Support Vector Machine 4678
- Computational Biology 4229
- Brain 4045
- Computer Simulation 3877
Recent Journals
- Scientific reports 5865
- Sensors (Basel, Switzerland) 4794
- PloS one 4011
- Neural networks : the official journal of the International Neural Network Society 2928
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1839
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1278
- IEEE journal of biomedical and health informatics 1129
- Journal of chemical information and modeling 994
- Nature communications 938
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 861
- Briefings in bioinformatics 850
- IEEE transactions on neural networks and learning systems 823