Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue.

Journal: Journal of biomedical optics
Published Date: Sep 24, 2024

Abstract

SIGNIFICANCE: Diffuse optical modalities such as broadband near-infrared spectroscopy (bNIRS) and hyperspectral imaging (HSI) represent a promising alternative for low-cost, non-invasive, and fast monitoring of living tissue. Particularly, the possibility of extracting the molecular composition of the tissue from the optical spectra deems the spectroscopy techniques as a unique diagnostic tool.

Authors

  • Ivan Ezhov
    Technical University of Munich, Department of Computer Science, Munich, Germany.
  • Kevin Scibilia
    Technical University of Munich, Department of Computer Science, Munich, Germany.
  • Luca Giannoni
    University of Florence, Department of Physics and Astronomy, Florence, Italy.
  • Florian Kofler
    Department of Computer Science, Institute for AI in Medicine, Technical University of Munich, Munich, Germany; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany; TranslaTUM, Central Institute for Translational Cancer Research of the Technical University of Munich, Munich, Germany; Helmholtz AI, Helmholtz Munich, Neuherberg, Germany.
  • Ivan Iliash
    Technical University of Munich, Department of Computer Science, Munich, Germany.
  • Felix Hsieh
    Technical University of Munich, Department of Computer Science, Munich, Germany.
  • Suprosanna Shit
    Department of Computer Science, Technical University of Munich (TUM), Munich, Germany.
  • Charly Caredda
    Univ Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR, Lyon, France.
  • Frédéric Lange
    University College London, Department of Medical Physics and Biomedical Engineering, London, United Kingdom.
  • Bruno Montcel
    CREATIS, Univ Lyon, CNRS UMR5220, INSERM U1044, Université Claude Bernard Lyon1, INSA Lyon, Villeurbanne, France. bruno.montcel@univ-lyon1.fr.
  • Ilias Tachtsidis
    Biomedical Optics Research Laboratory, University College London, London, UK.
  • Daniel Rueckert
    Biomedical Image Analysis (BioMedIA) Group, Department of Computing, Imperial College London, UK. Electronic address: d.rueckert@imperial.ac.uk.

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