AIMC Topic: Brain Chemistry
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Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue.
Journal of biomedical optics
Sep 24, 2024
SIGNIFICANCE: Diffuse optical modalities such as broadband near-infrared spectroscopy (bNIRS) and hyperspectral imaging (HSI) represent a promising alternative for low-cost, non-invasive, and fast monitoring of living tissue. Particularly, the possib...
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders.
Proceedings of the National Academy of Sciences of the United States of America
Aug 15, 2022
There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci (mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to extensive linkage disequilibrium (LD) of the genome, it is challengin...
Unsupervised anomaly detection using generative adversarial networks in H-MRS of the brain.
Journal of magnetic resonance (San Diego, Calif. : 1997)
Feb 13, 2021
The applicability of generative adversarial networks (GANs) capable of unsupervised anomaly detection (AnoGAN) was investigated in the management of quality of H-MRS human brain spectra at 3.0 T. The AnoGAN was trained in an unsupervised manner solel...
Intact metabolite spectrum mining by deep learning in proton magnetic resonance spectroscopy of the brain.
Magnetic resonance in medicine
Mar 12, 2019
PURPOSE: To develop a robust method for brain metabolite quantification in proton magnetic resonance spectroscopy ( H-MRS) using a convolutional neural network (CNN) that maps in vivo brain spectra that are typically degraded by low SNR, line broaden...
Thalamocortical dysrhythmia detected by machine learning.
Nature communications
Mar 16, 2018
Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It is characterized by a common oscillatory pattern in which resting-state alpha activity is replaced by cross-frequency coupling of low- and high-freq...
Detection of nanodiamonds in biological samples by EPR spectrometry.
Doklady. Biochemistry and biophysics
Jan 3, 2018
In model experiments in vitro, the applicability of the EPR spectrometry method for the detection of modified nanodiamonds (MNDs) in blood and homogenates of mouse organs has been established. A characteristic signal (g = 2.003, ΔH ≈ 10 G) is observe...
Determination of IMM-H004 and its active glucuronide metabolite in rat plasma and Ringer's solution by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 29, 2017
IMM-H004 is a novel neuroprotective agent and its glucuronide metabolite IMM-H004G has similar protective effects against cerebral ischemic injury in vivo and in vitro. A specific and sensitive ultra-performance liquid chromatography-tandem mass spec...
Identifying Weak Signals in Inhomogeneous Neuronal Images for Large-Scale Tracing of Sparsely Distributed Neurites.
Neuroinformatics
Oct 1, 2019
Tracing neurites constitutes the core of neuronal morphology reconstruction, a key step toward neuronal circuit mapping. Modern optical-imaging techniques allow observation of nearly complete mouse neuron morphologies across brain regions or even the...
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