Identification of four novel acute-on-chronic liver failure clusters with distinct clinical trajectories and mortality using machine learning methods.

Journal: Alimentary pharmacology & therapeutics
PMID:

Abstract

BACKGROUND AND AIMS: Machine learning (ML) can identify the hidden patterns without hypothesis in heterogeneous diseases like acute-on-chronic live failure (ACLF). We employed ML to describe and predict yet unknown clusters in ACLF.

Authors

  • Nipun Verma
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Pratibha Garg
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Arun Valsan
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Akash Roy
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Saurabh Mishra
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Parminder Kaur
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Sahaj Rathi
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Arka De
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Madhumita Premkumar
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Sunil Taneja
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Virendra Singh
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Radha K Dhiman
    Department of Hepatology Postgraduate Institute of Medical Education and Research Chandigarh India.
  • Ajay K Duseja
    Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Patrick Kamath
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.