Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes.

Journal: eLife
Published Date:

Abstract

BACKGROUND: Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the progression from prediabetes to diabetes.

Authors

  • Jiang Li
  • Yuefeng Yu
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Ying Sun
    CFAR and I2R, Agency for Science, Technology and Research, Singapore.
  • Yanqi Fu
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wenqi Shen
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lingli Cai
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Xiao Tan
    College of Food Science and Engineering, Northwest University, Xi'an 710069, China; School of Chemistry & Chemical Engineering, Yulin University, Yulin 719000, China.
  • Yan Cai
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, Jiangsu, China.
  • Ningjian Wang
    Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yingli Lu
    Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, M4N 3M5, Canada.
  • Bin Wang
    State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A&F University, Yangling 712100, China; New South Wales Department of Primary Industries, Wagga Wagga Agricultural Institute, Wagga Wagga 2650, Australia. Electronic address: bin.a.wang@dpi.nsw.gov.au.