An integrated machine learning model enhances delayed graft function prediction in pediatric renal transplantation from deceased donors.

Journal: BMC medicine
PMID: 39304842

Abstract

BACKGROUND: Kidney transplantation is the optimal renal replacement therapy for children with end-stage renal disease; however, delayed graft function (DGF), a common post-operative complication, may negatively impact the long-term outcomes of both the graft and the pediatric recipient. However, there is limited research on DGF in pediatric kidney transplant recipients. This study aims to develop a predictive model for the risk of DGF occurrence after pediatric kidney transplantation by integrating donor and recipient characteristics and utilizing machine learning algorithms, ultimately providing guidance for clinical decision-making.

Authors

  • Xiao-You Liu
    Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510163, China.
  • Run-Tao Feng
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Wen-Xiang Feng
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Wei-Wei Jiang
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Jian-An Chen
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Guang-Li Zhong
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Chao-Wei Chen
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Zi-Jian Li
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Jia-Dong Zeng
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Ding Liu
    College of Psychology, Shenzhen University, Shenzhen, People's Republic of China.
  • Song Zhou
    School of Mechanical and Electronic Engineering, Wuhan University of Technology, Wuhan 430070, China.
  • Jian-Min Hu
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Guo-Rong Liao
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Jun Liao
    Department of Pediatric Surgery, Affiliated Hospital of Guizhou Medical University, No. 28, Guiyi Street, Yunyan District, Guiyang 550002, P. R. China.
  • Ze-Feng Guo
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Yu-Zhu Li
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Si-Qiang Yang
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Shi-Chao Li
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Hua Chen
    Management College, Beijing Union University, Beijing, China.
  • Ying Guo
    National Institutes for Food and Drug Control, Beijing, 100050, China.
  • Min Li
    Hubei Provincial Institute for Food Supervision and Test, Hubei Provincial Engineering and Technology Research Center for Food Quality and Safety Test, Wuhan 430075, China.
  • Li-Pei Fan
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Hong-Yan Yan
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Jian-Rong Chen
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Liu-Yang Li
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
  • Yong-Guang Liu
    Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. liuyg168@smu.edu.cn.

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