Prediction of depressive symptoms severity based on sleep quality, anxiety, and gray matter volume: a generalizable machine learning approach across three datasets.

Journal: EBioMedicine
PMID: 39255547

Abstract

BACKGROUND: Depressive symptoms are rising in the general population, but their associated factors are unclear. Although the link between sleep disturbances and depressive symptoms severity (DSS) is reported, the predictive role of sleep on DSS and the impact of anxiety and the brain on their relationship remained obscure.

Authors

  • Mahnaz Olfati
    Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
  • Fateme Samea
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
  • Shahrooz Faghihroohi
    Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
  • Somayeh Maleki Balajoo
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
  • Vincent Küppers
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany; Department of Nuclear Medicine, University Hospital and Medical Faculty, University of Cologne, Cologne, Germany.
  • Sarah Genon
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
  • Kaustubh Patil
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany.
  • Simon B Eickhoff
    Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
  • Masoud Tahmasian
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, Germany; Department of Nuclear Medicine, University Hospital and Medical Faculty, University of Cologne, Cologne, Germany. Electronic address: m.tahmasian@fz-juelich.de.

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