Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report.

Journal: Translational vision science & technology
PMID:

Abstract

PURPOSE: The purpose of this study was to develop a deep learning algorithm for detecting and quantifying incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and complete retinal pigment epithelium and outer retinal atrophy (cRORA) in optical coherence tomography (OCT) that generalizes well to data from different devices and to validate in an intermediate age-related macular degeneration (iAMD) cohort.

Authors

  • Coen de Vente
    From the Department of Radiology, Nuclear Medicine and Anatomy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands (N.L., C.I.S., L.H.B., M.B., E.C., W.M.v.E., P.K.G., B.G., M.G., N.H., W.H., H.J.H., C.J., R.K., M.K., K.v.L., J.M., M.O., R.S., C. Schaefer-Prokop, S.S., E.T.S., C. Sital, J.T., K.V.V., C.d.V., W.X., B.d.W., M.P., B.v.G.); Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands (L.B.); Thirona, Nijmegen, the Netherlands (J.P.C., E.M.v.R.); Departments of Internal Medicine (T.D.) and Radiology (M.V.), Canisius-Wilhelmina Ziekenhuis, Nijmegen, the Netherlands; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (H.A.G.); GROW School of Oncology and Developmental Biology, Maastricht, the Netherlands (H.A.G.); Departments of Biomedical Physics and Engineering and Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, the Netherlands (L.v.H., I.I.); Department of Radiology, Zuyderland Medical Center, Heerlen, the Netherlands (J.K.); Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany (B.L.); Department of Radiology and Nuclear Medicine, Haaglanden Medical Center, The Hague, the Netherlands (T.v.R.V.); Department of Radiology, Meander Medical Center, Amersfoort, the Netherlands (C. Schaefer-Prokop, S.S.); and Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands (J.L.S.).
  • Philippe Valmaggia
    Institute of Molecular and Clinical Ophthalmology Basel (IOB), 4031, Basel, Switzerland.
  • Carel B Hoyng
  • Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany.
  • Mohammad M Islam
    Quantitative Healthcare Analysis (qurAI) Group, Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands.
  • Caroline C W Klaver
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands; Institute for Molecular and Clinical Ophthalmology, Basel, Switzerland.
  • Camiel J F Boon
    Department of Ophthalmology, Leiden University Medical Center, P. O. Box 9600, 2300 RC, Leiden, The Netherlands. cjfboon@hotmail.com.
  • Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany; GRADE Reading Center, Bonn, Germany; John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. Electronic address: Steffen.schmitz-valckenberg@ukbonn.de.
  • Adnan Tufail
    London, United Kingdom. Electronic address: Adnan.Tufail@moorfields.nhs.uk.
  • Marlene Saßmannshausen
    Department of Ophthalmology and GRADE Reading Center, University Hospital Bonn, Germany.
  • Clara I Sanchez