Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity.
Journal:
The journal of international advanced otology
PMID:
26915150
Abstract
OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.