Deep Learning Segmentation of Infiltrative and Enhancing Cellular Tumor at Pre- and Posttreatment Multishell Diffusion MRI of Glioblastoma.

Journal: Radiology. Artificial intelligence
PMID: 39166970

Abstract

Purpose To develop and validate a deep learning (DL) method to detect and segment enhancing and nonenhancing cellular tumor on pre- and posttreatment MRI scans in patients with glioblastoma and to predict overall survival (OS) and progression-free survival (PFS). Materials and Methods This retrospective study included 1397 MRI scans in 1297 patients with glioblastoma, including an internal set of 243 MRI scans (January 2010 to June 2022) for model training and cross-validation and four external test cohorts. Cellular tumor maps were segmented by two radiologists on the basis of imaging, clinical history, and pathologic findings. Multimodal MRI data with perfusion and multishell diffusion imaging were inputted into a nnU-Net DL model to segment cellular tumor. Segmentation performance (Dice score) and performance in distinguishing recurrent tumor from posttreatment changes (area under the receiver operating characteristic curve [AUC]) were quantified. Model performance in predicting OS and PFS was assessed using Cox multivariable analysis. Results A cohort of 178 patients (mean age, 56 years ± 13 [SD]; 116 male, 62 female) with 243 MRI timepoints, as well as four external datasets with 55, 70, 610, and 419 MRI timepoints, respectively, were evaluated. The median Dice score was 0.79 (IQR, 0.53-0.89), and the AUC for detecting residual or recurrent tumor was 0.84 (95% CI: 0.79, 0.89). In the internal test set, estimated cellular tumor volume was significantly associated with OS (hazard ratio [HR] = 1.04 per milliliter; < .001) and PFS (HR = 1.04 per milliliter; < .001) after adjustment for age, sex, and gross total resection (GTR) status. In the external test sets, estimated cellular tumor volume was significantly associated with OS (HR = 1.01 per milliliter; < .001) after adjustment for age, sex, and GTR status. Conclusion A DL model incorporating advanced imaging could accurately segment enhancing and nonenhancing cellular tumor, distinguish recurrent or residual tumor from posttreatment changes, and predict OS and PFS in patients with glioblastoma. Segmentation, Glioblastoma, Multishell Diffusion MRI © RSNA, 2024.

Authors

  • Louis Gagnon
    Department of Radiology and Nuclear Medicine, Université Laval, Québec, Québec, Canada.
  • Diviya Gupta
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • George Mastorakos
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Nathan White
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Vanessa Goodwill
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Carrie R McDonald
    Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA.
  • Thomas Beaumont
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Christopher Conlin
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Tyler M Seibert
    Radiation Medicine Department and Applied Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Radiology Department, University of California, San Diego, La Jolla, CA 92093, USA; Bioengineering Department, University of California, San Diego, La Jolla, CA 92093, USA.
  • Uyen Nguyen
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Jona Hattangadi-Gluth
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Santosh Kesari
    Pacific Neuroscience Institute, Santa Monica, CA 90404, USA.
  • Jessica D Schulte
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • David Piccioni
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Kathleen M Schmainda
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States.
  • Nikdokht Farid
    Department of Radiology, University of California San Diego School of Medicine, La Jolla, CA.
  • Anders M Dale
    From the Departments of Radiology (L.G., D.G., C.C., T.M.S., U.N., N.F., A.M.D., J.D.R.), Pathology (V.G.), Radiation Medicine and Applied Sciences (C.R.M., T.M.S., J.H.G.), Neurologic Surgery (T.B.), Bioengineering (T.M.S.), and Neurosciences (J.D.S., D.P., A.M.D.), University of California San Diego, 9500 Gillman Dr, La Jolla, CA 92093; Cortechs.ai, San Diego, Calif (G.M., N.W.); Department of Translational Neurosciences, Pacific Neuroscience Institute and Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, Calif (S.K.); and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wis (K.M.S.).
  • Jeffrey D Rudie
    Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 (J.D.R., L.X., A.K., J.M.E., T.C., I.M.N., S.M., J.C.G.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (J.D.R., A.M.R.); Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, Pa (X.L., J.W.); University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (M.T.D.); Mecklenburg Radiology Associates, Charlotte, NC (E.J.B.); Department of Radiology, University of Texas, Austin, Tex (R.N.B.); and Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, Pa (I.M.N.).

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