Machine Learning Models as Early Warning Systems for Neonatal Infection.

Journal: Clinics in perinatology
PMID:

Abstract

Neonatal infections pose a significant threat to the health of newborns. Associated morbidity and mortality risks underscore the urgency of prompt diagnosis and treatment with appropriate empiric antibiotics. Delay in treatment can be fatal; thus, early detection improves outcomes. However, diagnosing early is a challenge as signs and symptoms of neonatal infection are non-specific and overlap with non-infectious conditions. Machine learning (ML) offers promise in early detection, utilizing various data sources and methodologies. However, ML models require rigorous validation and consideration of various challenges, including false alarms and user acceptance requiring careful integration and ongoing evaluation for successful implementation.

Authors

  • Brynne A Sullivan
    Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, 1215 Lee Street, P.O. Box 800386, Charlottesville, VA 22947, USA. Electronic address: Brynne@virginia.edu.
  • Robert W Grundmeier
    Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 1024, Philadelphia, PA, 19104, USA.