Relationship between obstructive sleep apnea cardiac complications and sleepiness in children with Down syndrome.

Journal: Sleep medicine
PMID: 26847969

Abstract

OBJECTIVE/BACKGROUND: Children with Down syndrome (DS) have a high rate of pulmonary hypertension and sleepiness. They also have a high prevalence of obstructive sleep apnea syndrome (OSAS). We hypothesized that OSAS was associated with cardiovascular dysfunction and sleepiness in children with DS, and that this dysfunction was partly reversible.

Authors

  • Sofia Konstantinopoulou
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Ignacio E Tapia
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Ji Young Kim
    Division of Medical Oncology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 152-703, Republic of Korea.
  • Melissa S Xanthopoulos
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Jerilynn Radcliffe
    Clinical and Translational Research Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Meryl S Cohen
    Cardiac Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Brian D Hanna
    Cardiac Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Mary Pipan
    Trisomy 21 Program, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Christopher Cielo
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Allison J Thomas
    Clinical and Translational Research Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Babette Zemel
    Division of Gastroenterology, Nutrition, and Hepatology, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Raouf Amin
    Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Ruth Bradford
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Joel Traylor
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Justine Shults
    Clinical and Translational Research Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Carole L Marcus
    Sleep Center, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address: marcus@email.chop.edu.

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