Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4.

Journal: Computers in biology and medicine
PMID: 39488053

Abstract

BACKGROUND: Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated with this adverse reaction.

Authors

  • Ali Arab
    School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.
  • Bahareh Kashani
    Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada.
  • Miguel Cordova-Delgado
    BC Children's Hospital Research Institute, Vancouver, BC, Canada.
  • Erika N Scott
    BC Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Kaveh Alemi
    School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.
  • Jessica Trueman
    BC Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Gabriella Groeneweg
    Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, BC, Canada.
  • Wan-Chun Chang
    BC Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Catrina M Loucks
    BC Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Anesthesiology, Pharmacology & Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Colin J D Ross
    BC Children's Hospital Research Institute, Vancouver, BC, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Bruce C Carleton
    BC Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, BC, Canada. Electronic address: bcarleton@popi.ubc.ca.
  • Martin Ester
    School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.

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