AIMC Topic: Toll-Like Receptor 4
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Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis.
International journal of molecular sciences
May 1, 2025
Peri-implantitis (PI) is a chronic inflammatory disease that ultimately leads to the dysfunction and loss of implants with established osseointegration. Ferroptosis has been implicated in the progression of PI, but its precise mechanisms remain uncle...
Discovery of Active Ingredient of Yinchenhao Decoction Targeting TLR4 for Hepatic Inflammatory Diseases Based on Deep Learning Approach.
Interdisciplinary sciences, computational life sciences
Nov 19, 2024
Yinchenhao Decoction (YCHD), a classic formula in traditional Chinese medicine, is believed to have the potential to treat liver diseases by modulating the Toll-like receptor 4 (TLR4) target. Therefore, a thorough exploration of the effective compone...
Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4.
Computers in biology and medicine
Nov 1, 2024
BACKGROUND: Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated w...
Vibrational spectroscopy coupled with machine learning sheds light on the cellular effects induced by rationally designed TLR4 agonists.
Talanta
Apr 17, 2024
In this work, we present the potential of Fourier transform infrared (FTIR) microspectroscopy to compare on whole cells, in an unbiased and untargeted way, the capacity of bacterial lipopolysaccharide (LPS) and two rationally designed molecules (FP20...
Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14.
PloS one
Dec 27, 2017
The ability of soluble C. albicans 20A (serotype A) mannoprotein (CMP) to serve as a ligand for toll-like receptor 4 (TLR4) and its co-receptors was examined using commercially available and stably-transfected HEK293 cells that express human TLR4, MD...
[Effects of ATP on expression of inflammatory factors in endothelial progenitor cells induced by LPS and the mechanisms].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Dec 28, 2018
To investigate the effects of adenosine triphosphate (ATP) on expression of inflammatory factors induced by lipopolysaccharide (LPS) in endothelial progenitor cells (EPCs), and to elucidate the possible mechanisms.
Methods: Mononuclear cells were is...
[The β2GPI/aβ2GPI inhibits phagocytosis of oxidized low-density lipoprotein in THP-1 macrophages via activating TLR4].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Dec 1, 2018
Objective To investigate the effects of β2 glycoprotein I/anti-β2 glycoprotein I antibody complex (β2GPI/aβ2GPI) on lipid phagocytosis and class B scavenger receptor CD36 expression of macrophages, and the role of Toll-like receptor 4 (TLR4) during t...
Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.
Iranian journal of allergy, asthma, and immunology
Dec 1, 2016
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...
Tumor Necrosis Factor-alpha
Peroxidase
Metformin
Acute Lung Injury
Rats
Real-Time Polymerase Chain Reaction
Myeloid Differentiation Factor 88
Animals
Hypoglycemic Agents
RNA, Messenger
Toll-Like Receptor 4
Lipopolysaccharides
Blotting, Western
Male
Rats, Wistar
NF-kappa B
Lung
AMP-Activated Protein Kinases
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