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Toll-Like Receptor 4

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[Effects of ATP on expression of inflammatory factors in endothelial progenitor cells induced by LPS and the mechanisms].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
To investigate the effects of adenosine triphosphate (ATP) on expression of inflammatory factors induced by lipopolysaccharide (LPS) in endothelial progenitor cells (EPCs), and to elucidate the possible mechanisms.
 Methods: Mononuclear cells were is...

[The β2GPI/aβ2GPI inhibits phagocytosis of oxidized low-density lipoprotein in THP-1 macrophages via activating TLR4].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Objective To investigate the effects of β2 glycoprotein I/anti-β2 glycoprotein I antibody complex (β2GPI/aβ2GPI) on lipid phagocytosis and class B scavenger receptor CD36 expression of macrophages, and the role of Toll-like receptor 4 (TLR4) during t...

Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14.

PloS one
The ability of soluble C. albicans 20A (serotype A) mannoprotein (CMP) to serve as a ligand for toll-like receptor 4 (TLR4) and its co-receptors was examined using commercially available and stably-transfected HEK293 cells that express human TLR4, MD...

Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.

Iranian journal of allergy, asthma, and immunology
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...

Vibrational spectroscopy coupled with machine learning sheds light on the cellular effects induced by rationally designed TLR4 agonists.

Talanta
In this work, we present the potential of Fourier transform infrared (FTIR) microspectroscopy to compare on whole cells, in an unbiased and untargeted way, the capacity of bacterial lipopolysaccharide (LPS) and two rationally designed molecules (FP20...

Machine learning model identifies genetic predictors of cisplatin-induced ototoxicity in CERS6 and TLR4.

Computers in biology and medicine
BACKGROUND: Cisplatin-induced ototoxicity remains a significant concern in pediatric cancer treatment due to its permanent impact on quality of life. Previously, genetic association analyses have been performed to detect genetic variants associated w...