DDGemb: predicting protein stability change upon single- and multi-point variations with embeddings and deep learning.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Dec 26, 2024
Abstract
MOTIVATION: The knowledge of protein stability upon residue variation is an important step for functional protein design and for understanding how protein variants can promote disease onset. Computational methods are important to complement experimental approaches and allow a fast screening of large datasets of variations.