Development of a centrosome amplification-associated signature in kidney renal clear cell carcinoma based on multiple machine learning models.

Journal: Computational biology and chemistry
PMID: 39675190

Abstract

BACKGROUND: Centrosome amplification (CA) has been shown to be capable of initiating tumorigenesis with metastatic potential and enhancing cell invasion. We were interested in discovering how centrosome amplification-associated signature affects the prediction of prognosis and response to therapy in kidney renal clear cell carcinoma (KIRC).

Authors

  • Zhen Song
    School of Electronic and Information Engineering, South China University of Technology, Guangzhou, 510641, China.
  • Chunlei Xue
    Department of Urology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou 253000, China.
  • Hui Wang
    Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Lijian Gao
    Department of Urology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou 253000, China.
  • Haibin Song
    Department of Urology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou 253000, China.
  • Yuanyuan Yang
    Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.

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