Alantolactone exhibited anti-herpes simplex virus 1 (HSV-1) action in vitro.

Journal: Bioscience trends
PMID: 26781801

Abstract

The aim of this study was to determine the inhibitory action of alantolactone, a gradient of traditional Chinese medicine Inulae Radix (Tu-Mu-Xiang), on herpes simplex virus 1 (HSV-1). African green monkey kidney cells (Vero cells) were infected with HSV-1 and the protective effects of alantolactone on Vero cells were examined. At concentrations of 10(-6), 10(-7), and 10(-8) g/mL, alantolactone did not have a marked harmful effect on the viability of Vero cells according to an MTT assay. Based on the cytopathic effect (CPE) and MTT assays, alantolactone at these concentrations exhibited antiviral action and protected cells from being damaged by HSV-1. Results indicated that alantolactone had potent anti-HSV-1 action and provided evidence for use of Inulae Radix in the treatment of HSV-1 infection.

Authors

  • Caidan Rezeng
    Traditional Chinese and Tibetan Medicine of Medical College, Qinghai University.
  • Dongping Yuan
  • Jun Long
  • Dengdeng Suonan
  • Fang Yang
    College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, People's Republic of China.
  • Wenyuan Li
  • Li Tong
    Dept. of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332.
  • Pengcuo Jiumei

Keywords

External Resources

Popular Topics
Recent Journals