Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes.

Journal: Metabolism: clinical and experimental
Published Date:

Abstract

BACKGROUND AND AIM: Glutathione peroxidase (GPX) is a class of antioxidant enzymes that catalyze the reduction of hydrogen peroxide to water. GPX1 is the most abundant isoform and is expressed in all kidney cells. Isoprostane and advanced oxidation protein products (AOPP) were identified as markers of oxidative stress in patients with kidney disease. We investigated associations of GPX1 genotypes with kidney complications, and with plasma concentrations of isoprostane and AOPP in type 1 diabetic patients.

Authors

  • Kamel Mohammedi
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Department of Diabetology, Endocrinology and Nutrition, 46 rue Henri Huchard, 75018, Paris, France.
  • Thiago A Patente
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France; Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Dr. Arnaldo 455, CEP 01246903, São Paulo, SP, Brazil.
  • Naima Bellili-Muñoz
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France.
  • Fathi Driss
    INSERM, Research Unit 773, 16 rue Henri Huchard, 75018, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat Hospital, Department of Biochemistry, 46 rue Henri Huchard, 75018, Paris, France.
  • Hervé Le Nagard
    INSERM, Research Unit 1137 - IAME, 16 rue Henri Huchard, 75018, Paris, France.
  • Frédéric Fumeron
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, 16 rue Henri Huchard, 75018, Paris, France.
  • Ronan Roussel
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Department of Diabetology, Endocrinology and Nutrition, 46 rue Henri Huchard, 75018, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, 16 rue Henri Huchard, 75018, Paris, France.
  • Samy Hadjadj
    Institut du thorax, INSERM, CNRS, Université Nantes, CHU Nantes, Nantes, France.
  • Maria Lúcia Corrêa-Giannella
    Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Dr. Arnaldo 455, CEP 01246903, São Paulo, SP, Brazil; Centro de Terapia Celular e Molecular (NUCEL/NETCEM) da FMUSP, Avenida Dr. Arnaldo 455, CEP 01246903, São Paulo, SP, Brazil.
  • Michel Marre
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat Hospital, DHU FIRE, Department of Diabetology, Endocrinology and Nutrition, 46 rue Henri Huchard, 75018, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UFR de Médecine, 16 rue Henri Huchard, 75018, Paris, France.
  • Gilberto Velho
    INSERM, UMRS 1138, Centre de Recherche des Cordeliers, 15 rue de l'École de Médecine, 75006, Paris, France. Electronic address: gilberto.velho@inserm.fr.